Triethylamine → HCID 15549378, compound

Participants

Reaction Steps

To a stirred solution of N-(2-Allyloxy-4-cyanophenyl)-N′-(2-bromophenyl)-thiourea (900 mg, 2.32 mmol) and triethylamine (1 ml, 6.95 mmol) in methylene chloride was added dropwise at 0° methanesulfonyl chloride (360 μL, 4.64 mmol) under Ar. The reaction was stirred for 15 minutes at 0° and tlc showed no starting material present. The reaction mixture was chromatographed on silica gel eluting with methylene chloride to afford the title compound as a yellow solid (1.2 g, >100%). This was used in the next reaction without further purification.

Provenance & Evidence