HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-D-homophenylalanine → N-Boc-D-homophenylalanine L-serine Benzyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-D-homophenylalanine | HCID 2755954 | — |
| Reactant | Benzyl L-serinate--hydrogen chloride (1/1) | HCID 12930233 | — |
| Product | N-Boc-D-homophenylalanine L-serine Benzyl Ester | HCID 131722456 | 34.1% |
Reaction Steps
This compound was prepared from N-Boc-D-homophenylalanine (500 mg) and L-serine benzyl ester hydrochloride (415 mg), with purification by chromatography over silica gel (40% ethyl acetate/hexane) to afford title compound (290 mg) as a glassy solid: 1H NMR (400 Mz, CDCl3) δ1.42 (s, 9H), 1.97 (m, 1H), 2.18 (m, 1H), 2.70 (m, 2H), 3.98 (m, 2H), 4.19 (m, 1H), 4.64 (m, 1H), 5.29 (bs, 2H), 7.16-7.29 (m, 5H), and 7.36 (bs, 5H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06204279B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-ae78a53c14954357aefadabd9a6f1ba6 |
| Source note | uspto-grants-2001_03 |