反应详情

{5-Hydroxy-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate (8.3 g, 22 mmol) was dissolved in pyridine (200 ml) and treated with copper(I) iodide (5.2 g, 27 mmol) then heated under reflux for 18 h. The mixture was allowed to cool then evaporated to dryness. The residue was partitioned between water and ethyl acetate then filtered through kieselguhr. The organic layer was separated washed with more water then saturated brine solution then dried. Chromatography on silica gel eluting with 40-60 petrol and ethyl acetate gradient provided the two title compounds, (1.15 g, 27%) of furo[2,3-c]pyridin-5-ylmethyl acetate and (1.3 g, 22%) of [2-(trimethylsilyl)furo[2,3-c]pyridin-5-yl]methyl acetate.

1. temperaturethen heated
2. temperatureunder reflux for 18 h
3. temperatureto cool
4. customthen evaporated to dryness
5. customThe residue was partitioned between water and ethyl acetate
6. filtrationthen filtered through kieselguhr
7. customThe organic layer was separated
8. washwashed with more water
9. dry with materialsaturated brine solution then dried