HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(2-Pyridyloxy)-2-phenylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(2-Pyridyloxy)-2-phenylbenzoic acid methyl ester | HCID 54447164 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Pyridyloxy)-2-phenylbenzoic acid | HCID 23436505 | — |
Reaction Steps
A solution of the resultant ester from Example 6B (1.0 equivalent) in aqueous methanol is treated with NaOH (2.0 equivalents) and stirred until the reaction is deemed complete by TLC analysis. The mixture is acidified, diluted with water, and extracted into ethyl acetate which is dried and evaporated. Chromatography on silica gel provides the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06204293B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-008b54ceef7c4495ad7636260d012949 |
| Source note | uspto-grants-2001_03 |