HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Phenylterephthalic acid mono methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tesmilifene Hydrochloride | HCID 175534 | — |
| Reactant | Methyl 5-bromo-[1,1'-biphenyl]-2-carboxylate | HCID 54332024 | — |
| Reactant | HCID 178418416 | HCID 178418416 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Phenylterephthalic acid mono methyl ester | HCID 85732474 | — |
Reaction Steps
A solution of 4-bromo-2-phenylbenzoic acid methyl ester (1.0 equivalent), Pd(OAc)2 (0.05 equivalent) and DPPE (1.0 equivalent) is heated in DMF to 65° C. under 4 atm. of carbon monoxide until TLC analysis indicates that the reaction is complete. The reaction mixture is poured into water and extracted with ethyl acetate which is dried and evaporated. The product is purified by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06204293B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-bcd4b97899f04a25800c13125ec66453 |
| Source note | uspto-grants-2001_03 |