HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 70226397, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | methyl (2S)-2-amino-4-(methylsulfanyl)butanoate | HCID 64684 | — |
| Reactant | HCID 22171396 | HCID 22171396 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 70226397 | HCID 70226397 | 82% |
Reaction Steps
The compound prepared in Example 975A was hydrolyzed with 1N aqueous NaOH and the carboxylic acid was coupled with (L)-methionine methyl ester by using coupling reagents. After flash column chromatography (1.5:1 =hexane/ethyl acetate), the desired compound was obtained (82% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06204293B1 |
| Source dataset | uspto-grants-2001_03 |
| ORD ID | ord-db664008c9b449a986aa22e67214b623 |
| Source note | uspto-grants-2001_03 |