2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 70225591, compound

Participants

Reaction Steps

To a solution of N-[4-(3-cyclohexyl-1-(4-methoxybenzyloxy)prop-2-yloxymethyl)-2-(2-methylphenyl)benzoic acid methyl ester (Example 1051B, 360 mg) in dichloromethane (2 mL) was added water (5 drops), and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (190 mg). After 50 min, the reaction was diluted with EtOAc/hexane (1:1, 10 mL), dried (MgSO4), and filtered through a pad of silica gel. The filtrate was concentrated, and the residue was purified by silica gel chromatography eluting with 20%-30% EtOAc/hexane to give the title compound (230 mg, 90%) as a colorless oil.

Provenance & Evidence