Acetic Acid → HCID 53905698, compound

HRID 1532929Notes

Reaction equation

HRID 1532929 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:9][CH:8]=1)[CH3:2].[C:19]([OH:22])(=[O:21])[CH3:20]>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:18])[CH:5]=[CH:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]([CH2:16][CH3:17])[CH2:14][CH3:15])=[CH:11][C:12]=1[O:22][C:19](=[O:21])[CH3:20])[CH3:2]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53659812HCID 53659812, compound

Product 1

HCID 53905698HCID 53905698, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(4-Diethylaminophenyl)-2-propenic acid ethyl ester (1 g, 3.80 mmol) was dissolved in 5 ml of pyridine. To this was added 0.8 ml of anhydrous acetic acid and it was allowed to react at room temperature for 24 h. After the solvent was removed in vacuo, purification was carried out by silica gel column chromatography (toluene/ethyl acetate 93:7 as a developing solvent) to give 1.2 g of the desired product in a quantitative yield.

Workup

  1. customto react at room temperature for 24 h
  2. customAfter the solvent was removed in vacuo, purification

Sources & evidence

ORD record
ord-359e16a419bd44aa85add7985bf9405f
Source dataset
uspto-grants-2001_03
Patent number
US06207365B1

Reaction notes

Loading…