Acetic Acid → 3-(2-Acetoxy-4, 6-dimethoxyphenyl)-2-methyl-2-propenic acid ethyl ester

HRID 1532931Notes

Reaction equation

HRID 1532931 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[C:5]([CH3:17])=[CH:6][C:7]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=1)[CH3:2].[C:19]([OH:22])(=[O:21])[CH3:20]>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:18])[C:5]([CH3:17])=[CH:6][C:7]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([O:15][CH3:16])=[CH:9][C:8]=1[O:22][C:19](=[O:21])[CH3:20])[CH3:2]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53931368HCID 53931368, compound

Product 1

HCID 536889433-(2-Acetoxy-4, 6-dimethoxyphenyl)-2-methyl-2-propenic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-(4,6-Dimethoxyphenyl)-2-methyl-2-propenic acid ethyl ester (1 g, 3.76 mmol) was dissolved in 5 ml of pyridine. To this was added 0.8 ml of anhydrous acetic acid and it was allowed to react at room temperature for 24 h. After the solvent was removed in vacuo, purification was carried out by silica gel column chromatography (toluene/ethyl acetate 93:7 as a developing solvent) to give 1.2 g of the desired product in a quantitative yield.

Workup

  1. customto react at room temperature for 24 h
  2. customAfter the solvent was removed in vacuo, purification

Sources & evidence

ORD record
ord-23c11383e88d40daa411fac97d43f933
Source dataset
uspto-grants-2001_03
Patent number
US06207365B1

Reaction notes

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