p-Toluenesulfonic acid → HCID 54149411, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2.5 g of 2-[bis(diethoxyphosphoryl)methyl]maleic acid disodium salt in 50 ml of acetone is added with 2.13 g of para-toluenesulphonic acid. After 8 minutes under stirring, the formed sodium para-toluenesulphonate is separated by filtration and solvent is evaporated under reduced pressure. The residue is redissolved in 7.5 ml of anhydrous tetrahydrofuran and cooled to 0° C., then it is added dropwise with 3.8 ml of trifluoroacetic anhydride. The reaction mixture is refluxed for 30 minutes, then it is cooled to room temperature and concentrated to dryness. The residue is treated with ethyl ether, filtered and concentrated to dryness. This work up is repeated twice with toluene. 2.7 g of the product are obtained.

Provenance & Evidence