Triethylamine → HCID 53734866, compound

Participants

Reaction Conditions

Reaction Steps

1.5 g (8.5 mmol) of 4,5-dichloro-6-ethylpyrimidine, 1.7 g (8.5 mmol) of 1-allyl-4-amino-2-phenylpyrrolidine (prepared from 1-allyl-2-phenylpyrrolidin--4-ol analogously to the route described in Example A) and 2 ml (4 mmol) of triethylamine were heated for 12 hours at 85° C. After cooling, the mixture was diluted with water and extracted with ether, and the organic phase was washed with saturated NaCl solution. After drying and concentrating, the residue was purified by column chromatography using petroleum ether/ethyl acetate (9:1, 8:2). This gave 0.95 g (33% of theory) of a colorless syrup (diastereomers 1:1)

Provenance & Evidence