49773-19-5 → HCID 21952219, compound

HRID 1532969Notes

Reaction equation

HRID 1532969 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[C:17]3[CH:25]=[C:24]([C:26]4[O:30][C:29]([CH:31]=O)=[CH:28][CH:27]=4)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:33][S:34]([CH2:36][CH2:37][NH2:38])=[O:35]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([NH:15][C:16]2[C:17]3[CH:25]=[C:24]([C:26]4[O:30][C:29]([CH2:31][NH:38][CH2:37][CH2:36][S:34]([CH3:33])=[O:35])=[CH:28][CH:27]=4)[N:23]=[CH:22][C:18]=3[N:19]=[CH:20][N:21]=2)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 434785549773-19-5HCID 219520464-(4-Benzyloxyanilino)-6-(5-formylfuran-2-yl) pyrido[3,4-d]pyrimidine

Product 1

HCID 21952219HCID 21952219, compound

Procedure

In an analogous manner to Example 1, 5-(4-(4-Benzyloxy-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl)-furan-2-carbaldehyde and [2-(methanesulphinyl)ethyl]amine were converted into the title compound; δH [2H6]-DMSO 10.20 (1H, b), 9.11 (1H, s), 8.67 (1H, s), 8.59 (1H, s), 7.72 (2H, d), 7.53−7.30 (5H, m), 7.17−7.04 (3H, m), 6.52 (1H, d), 5.15 (2H, s), 3.87 (2H, s), 3.08−2.75 (4H, m), 2.55 (3H, s); m/z 514 (M+1)+.

Sources & evidence

ORD record
ord-9aec2a6f3c144c788cd6cfada622260b
Source dataset
uspto-grants-2001_03
Patent number
US06207669B1

Reaction notes

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