Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 22011794 | HCID 22011794 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Product | HCID 69686798 | HCID 69686798 | — |
Reaction Steps
A mixture of (±)-4-(4-chlorobenzyl)-2-[(2-ethoxy-iodophenoxy)methyl]-morpholine (1.0 g, 2.1 mmol), zinc cyanide (0.17 g, 1.4 mmol) and tetrakis(triphenylphosphino)palladium(O) (349 mg, 0.3 mmol) in DMF (15 ml) was heated to 80° C. for 3 h. Water was added and the solids were filtered off. The filtrate was extracted twice with ethyl acetate. Drying over magnesium sulfate was followed by evaporation. The crude product was dissolved in ether and an ethereal solution of oxalic acid was added to precipitate the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06207662B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-fe65429694ee4b67ba00f8a45cb0aacb |
|---|
| Source note | uspto-grants-2001_03 |
|---|
