(R)-2-(4-Hydroxyphenyl)-1-methylethylcarbamic acid, t-butyl ester → (R)-4-(2-t-Butoxycarbonylaminopropyl)phenoxymethyl-(3-benzyloxypropyl)phosphinic acid, n-butyl ester

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Reaction Steps

The title compound was prepared from 3-benzyloxypropyl-(4-chlorobenzenesulfonyloxymethyl)phosphinic acid, n-butyl ester and (R)-2-(4-hydroxyphenyl)-1-methylethylcarbamic acid, t-butyl ester according to the method described in Procedure 24. The crude product was purified by chromatography, eluting with dichloromethane containing 3% methanol, to give an oil.

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