Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 1,3-Propanediol | HCID 10442 | — |
| Reactant | 3-Acetyloxy-1-phenylindole | HCID 22012240 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 15390685 | HCID 15390685 | — |
Reaction Steps
A mixture of 3-acetyloxy-1-phenylindole (24 g), 1,3-dihydroxypropane (240 ml), and conc. sulfuric acid (10 ml) was heated to 80° C. for 2 h. Water was added followed by extraction with ether. The ether phase was dried over magnesium sulfate followed by removal of solvent in vacuo giving 3-(1-phenyl-3-indolyloxy)-1-propanol, sufficiently pure for use in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06207677B1 |
|---|
| Source dataset | uspto-grants-2001_03 |
|---|
| ORD ID | ord-d102895e417c4d7fa0738a58d7af1d1e |
|---|
| Source note | uspto-grants-2001_03 |
|---|
