4-(4-Fluorophenyl)piperidine → HCID 15390679, compound

HRID 1533008Notes

Reaction equation

HRID 1533008 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][CH:9]1[C:13]2[CH:14]=[C:15]([F:18])[CH:16]=[CH:17][C:12]=2[O:11][CH2:10]1)(=O)=O.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[F:18][C:15]1[CH:16]=[CH:17][C:12]2[O:11][CH2:10][CH:9]([CH2:8][CH2:7][CH2:6][N:29]3[CH2:30][CH2:31][CH:26]([C:23]4[CH:22]=[CH:21][C:20]([F:19])=[CH:25][CH:24]=4)[CH2:27][CH2:28]3)[C:13]=2[CH:14]=1

Participants

3

Reactant 2

HCID 27591364-(4-Fluorophenyl)piperidineHCID 22012208HCID 22012208, compound

Product 1

HCID 15390679HCID 15390679, compound

Procedure

The title compound, 11a, was prepared from 3-(2,3-dihydro-5-fluoro-benzofuran-3-yl)-1-propyl methanesulfonate (4.2 g) and 4-(4-fluorophenyl)piperidine (5.5 g) by the method described in EXAMPLE 2. Yield: 1.8 g, mp: 83-85° C.

Sources & evidence

ORD record
ord-8474cd5d63d443359d856740e30c5945
Source dataset
uspto-grants-2001_03
Patent number
US06207677B1

Reaction notes

Loading…