反应详情

1-[2-(2-Methoxybenzoyl)imidazol-1-yl]-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butane (1.1 g) (see Preparation 57) was dissolved in methanol (20 ml), Amberlyst 15 (trade mark) ion-exchange resin (0.11 g) added and the mixture stirred at room temperature for 5 days. The resin was removed by filtration through a short column of Arbacel (trade mark) filter aid and the solvent removed from the filtrate under reduced pressure to give a residue. This was chromatographed on silica gel eluting with 97:3, by volume, dichloromethane:methanol to give 3-(3,4-dichlorophenyl)-4-[2-(2-methoxybenzoyl)-imidazol-1-yl]butan-1-ol (0.31 g) as a white foam.

1. customThe resin was removed by filtration through a short column of Arbacel (trade mark)
2. filtrationfilter aid
3. customthe solvent removed from the filtrate under reduced pressure
4. customto give a residue
5. customThis was chromatographed on silica gel eluting with 97:3, by volume, dichloromethane