HRID1533115

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2723631

N,N'-Dimethylthiourea

C3H8N2S

结构：O=C1c2cccc(-c3ccc(C(F)(F)F)cc3)c2CC1Br

HCID21702063

未命名化合物

PRODUCTS

生成物

结构：Br.CN=C1SC2Cc3c(-c4ccc(C(F)(F)F)cc4)cccc3C2(O)N1C

HCID20638583

未命名化合物

结构：CN=C1SC2Cc3c(-c4ccc(C(F)(F)F)cc4)cccc3C2(O)N1C

HCID20638584

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

426 mg (1.2 mmol) of 2-bromo-4-(4-trifluoromethylphenyl)-1-indanone and 130.2 mg (1.25 mmol) of N,N′-dimethylthiourea are dissolved in 10 ml of acetone and stirred at room temperature for 4 h. The precipitate is filtered off with suction, washed with acetone and dried in vacuo. The hydrobromide of 3-methyl-2-methylimino-7-(4-trifluoromethylphenyl)-2,3,8,8a-tetrahydroindeno[1,2-d]thiazol-3a-ol is obtained with a melting point of 202-204° C.

WORKUP

后处理

filtrationThe precipitate is filtered off with suction
washwashed with acetone
customdried in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9dbe5b06f45643caa7654a4ed1bce217
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06207689B1
来源说明: uspto-grants-2001_03

反应 SMILES

[Br:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[C:3]1=[O:21].[CH3:22][NH:23][C:24]([NH:26][CH3:27])=[S:25]>CC(C)=O>[BrH:1].[CH3:27][N:26]1[C:3]2([OH:21])[C:4]3[CH:5]=[CH:6][CH:7]=[C:8]([C:11]4[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=4)[C:9]=3[CH2:10][CH:2]2[S:25][C:24]1=[N:23][CH3:22].[CH3:27][N:26]1[C:3]2([OH:21])[C:4]3[CH:5]=[CH:6][CH:7]=[C:8]([C:11]4[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=4)[C:9]=3[CH2:10][CH:2]2[S:25][C:24]1=[N:23][CH3:22]