Isocyanate → HCID 22707346, compound

HRID 1533137Notes

Reaction equation

HRID 1533137 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20](OCC)=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C(O[C:34]([N:36]1CCN(C2C3C(=CC(F)=C(F)C=3)N=CN=2)CC1)=O)(C)(C)C.O([C:61]1[CH:66]=[CH:65][C:64]([N:67]=C=O)=[CH:63][CH:62]=1)C1C=CC=CC=1.[N-]=[C:71]=O.[N-]=C=S>>[C:34]([C:61]1[CH:62]=[CH:63][C:64]([NH:67][C:6]([N:8]2[CH2:9][CH2:10][N:11]([C:14]3[C:23]4[C:18](=[CH:19][C:20]([CH3:71])=[C:21]([O:24][CH3:25])[CH:22]=4)[N:17]=[CH:16][N:15]=3)[CH2:12][CH2:13]2)=[O:7])=[CH:65][CH:66]=1)#[N:36]

Participants

6

Reactant 5

HCID 105034IsocyanateHCID 27348964-Phenoxyphenyl isocyanateHCID 11452048HCID 11452048, compoundHCID 54134689HCID 54134689, compoundHCID 178418790HCID 178418790, compound

Product 1

HCID 22707346HCID 22707346, compound

Procedure

In the following Examples 335-338, substantially the same procedure as in Example 329 was repeated, except that 4-(7-ethoxy-6-methoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester obtained in Reference Example 8 was used in place of 4-(6,7-difluoro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester, and 4-phenoxyphenyl isocyanate, or in its place, the corresponding isocyanate or isothiocyanate was used, to give the desired compound.

Workup

  1. customobtained in Reference Example 8

Sources & evidence

ORD record
ord-d9a2031291b245a7b37928813b20e7a8
Source dataset
uspto-grants-2001_03
Patent number
US06207667B1

Reaction notes

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