Isocyanate → HCID 22707689, compound

HRID 1533145Notes

Reaction equation

HRID 1533145 reaction equation
C(OC(N1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]4[O:27][CH2:26]C[O:24][C:21]=4[CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(N1CCN([C:41]2[C:50]3[C:45](=CC(F)=[C:48](F)[CH:49]=3)[N:44]=[CH:43][N:42]=2)CC1)=O)(C)(C)C.[N-]=C=O.[N-:56]=[C:57]=[S:58]>>[CH2:26]1[O:27][C:20]2[CH:19]=[C:18]3[C:23]([C:14]([N:11]4[CH2:10][CH2:9][N:56]([C:57](=[S:58])[NH:42][CH2:41][C:50]5[CH:45]=[N:44][CH:43]=[CH:48][CH:49]=5)[CH2:13][CH2:12]4)=[N:15][CH:16]=[N:17]3)=[CH:22][C:21]=2[O:24]1

Participants

5

Reactant 4

HCID 105034IsocyanateHCID 11462903HCID 11462903, compoundHCID 54134689HCID 54134689, compoundHCID 178418790HCID 178418790, compound

Product 1

HCID 22707689HCID 22707689, compound

Procedure

In the following Examples 372-375, substantially the same procedure as in Example 329 was repeated, except that 4-(6,7-ethylenedioxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester obtained in Reference Example 14 was used in place of 4-(6,7-difluoro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester, and the corresponding isocyanate (used in Example 372) or isothiocyanate was used in place of 4-phenoxyphenyl isocyanate, to give the desired compound.

Workup

  1. customobtained in Reference Example 14

Sources & evidence

ORD record
ord-9e877b756647409790891e9a2be4e4aa
Source dataset
uspto-grants-2001_03
Patent number
US06207667B1

Reaction notes

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