HCID 11270763, compound → HCID 11260252, compound

HRID 1533146Notes

Reaction equation

HRID 1533146 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][C:15]=2C(OCC)=O)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C(OC(N1CCN(C2[C:55]3[C:50](=[CH:51][C:52](F)=[C:53](F)[CH:54]=3)N=CN=2)CC1)=O)(C)(C)C.[N-:58]=[C:59]=S>>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][CH:15]=[C:14]2[N:11]1[CH2:10][CH2:9][N:8]([C:6]([NH:58][C:59]2[CH:23]=[CH:22][C:21]([O:24][C:50]3[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=3)=[CH:20][CH:19]=2)=[O:7])[CH2:13][CH2:12]1

Participants

4

Reactant 3

HCID 11270763HCID 11270763, compoundHCID 54134689HCID 54134689, compoundHCID 178418790HCID 178418790, compound

Product 1

HCID 11260252HCID 11260252, compound

Procedure

In the following Examples 408-410, substantially the same procedure as in Example 329 was repeated, except that 4-(6,7-dimethoxy-3-ethoxycarbonyl-4-quinolyl)-1-piperazinecarboxylic acid tert-butyl ester obtained in Reference Example 18 was used in place of 4-(6,7-difluoro-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester, and the corresponding isothiocyanate was used in place of 4-phenoxyphenyl isocyanate (used in Example 408), to give the desired compound.

Workup

  1. customobtained in Reference Example 18

Sources & evidence

ORD record
ord-d53ad6066c02451688f1209f10260025
Source dataset
uspto-grants-2001_03
Patent number
US06207667B1

Reaction notes

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