2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol → 2,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde

HRID 15332Notes

Reaction equation

HRID 15332 reaction equation
[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1>ClCCl.[O-2].[O-2].[Mn+4]>[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH:10]=[O:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 574231212,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

Product 1

HCID 574231162,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehydeYield 70%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol (1.31 g, 8.7 mmol) was dissolved in dichloromethane (100 ml) and treated with manganese dioxide (6 g, 69 mmol) at ambient temperature with vigorous stirring for 18 h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness to provide the desired compound (0.9 g, 70%).

Workup

  1. filtrationThe mixture was filtered through kieselguhr
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-6c66c9facbec48ee8f5ce4b4d05f60cc
Source dataset
uspto-grants-2010_06
Patent number
US07732461B2

Reaction notes

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