反应详情

To a suspension of benzyl (2-benzyloxyphenyl)acetate (100 g) in ethanol (500 ml) was added a solution of sodium hydroxide (36 g) in water (300 ml). After being stirred for 16 hours, the mixture was concentrated under reduced pressure. Water was added to the residue and the mixture was washed with diethyl ether. The aqueous layer was acidified by concentrated-hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried and evaporated in vacuo. The residual oil was crystallized from diisopropyl ether to afford (2-benzyloxyphenyl)acetic acid (28 g).

1. concentrationthe mixture was concentrated under reduced pressure
2. additionWater was added to the residue
3. washthe mixture was washed with diethyl ether
4. concentrationby concentrated-hydrochloric acid solution
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with brine
7. customdried
8. customevaporated in vacuo
9. customThe residual oil was crystallized from diisopropyl ether