反应详情

To a solution of methyl (2RS,3SR)-2-(2-benzyloxyphenyl)-3-cyclohexyl-3-hydroxypropionate (500 mg) in ethanol (10 ml) was added a 1N aqueous solution of sodium hydroxide (5 ml). After being stirred for 24 hours the mixture was concentrated under reduced pressure. The residue was washed with diethyl ether and acidified by 1N aqueous hydrochloric acid solution. The separated oily product was extracted by ethyl acetate. The organic layer was washed with brine, dried and evaporated under reduced pressure to afford (2RS,3SR)-2-(2-benzyloxyphenyl)-3-cyclohexyl-3-hydroxypropionic acid (321 mg).

1. concentrationwas concentrated under reduced pressure
2. washThe residue was washed with diethyl ether
3. extractionThe separated oily product was extracted by ethyl acetate
4. washThe organic layer was washed with brine
5. customdried
6. customevaporated under reduced pressure