Sodium Hydroxide → HCID 22012326, compound

Participants

Reaction Steps

To a solution of ethyl (2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-cyclohexyl-3-hydroxypropionate (4.2 g) in ethanol (50 ml) was added 1M sodium hydroxide solution (26.2 ml) at room temperature. After being stirred for 1.5 hours at the same temperature, the mixture was concentrated in vacuo. The residue was dissolved in 1N hydrochloric acid (50 ml) and ethyl acetate (100 ml) and the organic layer was washed with brine, dried over magnesium sulfate, and concentrated in vacuo. The residue was crystallized from n-hexane to give (2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-cyclohexyl-3-hydroxypropionic acid (1.43 g).

Provenance & Evidence