Water → HCID 22012434, compound

Participants

Reaction Steps

To a solution of 1,4-benzodioxane-6-acetic acid (5.0 g) and potassium carbonate (2.13 g) in dimethylformamide (20 ml) was added benzyl bromide (4.84 g) at room temperature. After being stirred at the same temperature for 3 hours, the mixture was poured into water (200 ml) and extracted with diethyl ether (150 ml). The organic layer was washed with 5% hydrochloric acid solution, 1M aqueous sodium bicarbonate solution and brine, dried over magnesium sulfate, and concentrated in vacuo to afford benzyl 1,4-benzodioxane-6-acetate (7.08 g) as an oil.

Provenance & Evidence