HCID 22012440, compound → HCID 22012474, compound

Participants

Reaction Steps

A solution of (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxy-phenyl)-3-(4-methoxycarbonylphenyl)propionic acid (80 mg) in 1N aqueous sodium hydroxide solution (1.2 ml) and methanol (5 ml) was stirred at ambient temperature for 18 hours. The reaction was quenched with iN-hydrochloric acid and then the resulting mixture was diluted with ethyl acetate. The layers were separated and the organic layer was washed with brine. The organic layer was dried and evaporated to afford (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(4-carboxyphenyl)propionic acid (60 mg).

Provenance & Evidence