Hydrogen chloride-ethyl acetate → HCID 178441760, compound

HRID 1533272Notes

Reaction equation

HRID 1533272 reaction equation
[OH:1][CH:2]([C:16]1[N:17]=[C:18]([CH2:28][CH2:29][CH2:30][CH3:31])[N:19](C(OC(C)(C)C)=O)[CH:20]=1)[CH:3]([C:7]1[CH:12]=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)[C:4]([OH:6])=[O:5].C(OCC)(=O)C.[ClH:38]>>[ClH:38].[OH:1][CH:2]([C:16]1[N:17]=[C:18]([CH2:28][CH2:29][CH2:30][CH3:31])[NH:19][CH:20]=1)[CH:3]([C:7]1[CH:12]=[CH:11][C:10]2[O:13][CH2:14][O:15][C:9]=2[CH:8]=1)[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22012379HCID 22012379, compound

Product 1

HCID 178441760HCID 178441760, compound

Procedure

A solution of (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1-tert-butoxycarbonyl-1H-imidazol-4-yl)propionic acid (250 mg) in 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at ambient temperature for 18 hours. The solution was evaporated in vacuo and then the residue was solidified with ether. Resulting powder was collected by filtration and dried to afford (2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1H-imidazol-4-yl)propionic acid hydrochloride (65 mg).

Workup

  1. customThe solution was evaporated in vacuo
  2. customResulting powder
  3. filtrationwas collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-1faf1397cb87476a8d4a72cf0171644c
Source dataset
uspto-grants-2001_03
Patent number
US06207686B1

Reaction notes

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