Carbon tetrabromide → HCID 53704481, compound

Participants

Reaction Steps

To a solution of 1-tert-butoxycarbonyl-2-n-butyl-4-(hydroxymethyl)imidazole (4.43 g) in dichloromethane (80 ml) was added triphenylphosphine (5.48 g) followed by carbon tetrabromide (6.93 g) at ambient temperature and the mixture was stirred for 30 minutes. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography (eluent; n-hexane:ethyl acetate=4:1) to give 1-tert-butoxycarbonyl-2-n-butyl-4-(bromomethyl)imidazole (5.09 g) as a colorless oil.

Provenance & Evidence