Sodium Hydroxide → HCID 70247655, compound

Participants

Reaction Steps

To a solution of N-[(2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-cyclohexyl-3-hydroxypropionyl]-L-tryptophan methyl ester (160 mg) in MeOH (2 ml) was added 1M aqueous sodium hydroxide solution (1 ml) at room temperature. After being stirred for 1 hours at the same temperature, the mixture was concentrated in vacuo. The residue was dissolved in 1N hydrochloric acid (5 ml) and ethyl acetate (10 ml) and the organic layer was washed with brine, dried over magnesium sulfate, and concentrated in vacuo to give N-[(2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-cyclohexyl-3-hydroxypropionyl]-L-tryptophan (150 mg).

Provenance & Evidence