Hydrochloric Acid → HCID 70247690, compound

Participants

Reaction Steps

A solution of N-[(2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1-tert-butoxycarbonyl-1H-imidazol-4-yl)propionyl]-L-tryptophan methyl ester (118 mg) in 1N aqueous sodium hydroxide solution (1.0 ml) and methanol (5.0 ml) was stirred at ambient temperature for 2 hours. The solution was acidified with 1N hydrochloric acid and the mixture was diluted with ethyl acetate followed by washing with brine. The organic layer was dried and evaporated to afford crude N-[(2RS,3SR)-3-hydroxy-2-(3,4-methylenedioxyphenyl)-3-(2-n-butyl-1-tert-butoxycarbonyl-1H-imidazol-4-yl)propionyl]-L-tryptophan.

Provenance & Evidence