Pyridine → HCID 20640759, compound

Participants

Reaction Steps

To a solution of Nα-[(2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-hydroxyheptanoyl]-L-tryptophan benzyl ester (255 mg) in dichloromethane (5 ml) were added pyridine (74 mg), acetic anhydride (72 mg) and 4-(dimethylamino)pyridine (11 mg) at 5° C. and the mixture was stirred at ambient temperature for 18 hours. The mixture was diluted with ethyl acetate (20 ml) and the solution was washed with 0.5N hydrochloric acid (20 ml×2), saturated sodium bicarbonate aqueous solution (20 ml×2) and brine (20 ml) successively and the organic layer was dried over magnesium sulfate. The solution was filtered and concentrated in vacuo to give Nα-[(2RS,3RS)-2-(3,4-methylenedioxyphenyl)-3-acetoxyheptanoyl]-L-tryptophan benzyl ester as an oil.

Provenance & Evidence