Thioglycolic Acid → (Quinolin-2-ylsulfanyl)-acetic acid

HRID 1533460Notes

Reaction equation

Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[SH:12][CH2:13][C:14]([OH:16])=[O:15]>>[N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[S:12][CH2:13][C:14]([OH:16])=[O:15]

Participants

Reactant 2

HCID 1133Thioglycolic Acid

HCID 119282-Chloroquinoline

Product 1

HCID 408543(Quinolin-2-ylsulfanyl)-acetic acid

Procedure

The present invention provides a single stage method for the production of 2-(quinolylthio)acetic acid by reacting 2-chloroquinoline with mercaptoacetic acid; the desired 2-(quinolylthio)acetic acid is obtained with high purity and yield.

Sources & evidence

ORD record: ord-e2fff8603ddd4460848826b93402addc
Source dataset: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06207833B1

Reaction notes

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