HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1533481Generated: October 26, 2026
2-Mercaptobenzoic Acid → 2-(3,5-Dimethoxyphenylthio)benzoic acid
https://huagongshe.com/reaction/1533481
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Chloro-3,5-dimethoxybenzene | HCID 81502 | — |
| Catalyst | Copper | HCID 23978 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(3,5-Dimethoxyphenylthio)benzoic acid | HCID 11033590 | 10% |
Reaction Steps
A mixture of thiosalicylic acid (44 g), 5-chloro-1,3-dimethoxybenzene (49.2 g), potassium carbonate (78 g), copper (powder) (4.3 g) and copper(I) iodide (4.3 g) in N-methyl-2-pyrrolidone (390 ml) was stirred at 190° C. for 10 hours. The reaction mixture was treated by the same procedure as in Example 1 to give 8.0 g (10%) of a compound of the indicated formula (10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06207837B1 |
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| Source dataset | uspto-grants-2001_03 |
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| ORD ID | ord-6563f985266e4c34a0877745579864e9 |
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| Source note | uspto-grants-2001_03 |
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