3-(Methylthio)phenylacetic acid → N-[(3-methylthiophenyl)acetyl]alanine Iso-butyl Ester

HRID 1533563Notes

Reaction equation

HRID 1533563 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=1.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([S:2][CH3:1])[CH:4]=1)[CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 27374613-(Methylthio)phenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481777N-[(3-methylthiophenyl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I′ above, and using 3-methylthiophenylacetic acid (CAS# 18698-73-2) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-053bd372462e4b889607841aa1a36cde
Source dataset
uspto-grants-2001_03
Patent number
US06207710B1

Reaction notes

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