2-(3-Methyl-1,2-oxazol-5-yl)acetic acid → N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

HRID 1533565Notes

Reaction equation

HRID 1533565 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH2:7][C:8]([OH:10])=O)[O:4][N:3]=1.[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH2:18])[CH:12]([CH3:14])[CH3:13]>>[CH2:11]([O:15][C:16](=[O:20])[C@H:17]([CH3:19])[NH:18][C:8](=[O:10])[CH2:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)[CH:12]([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 41955322-(3-Methyl-1,2-oxazol-5-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481782N-[(3-methylisoxazol-5yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure I′ above, and using (3-methyl-isoxazol-5-yl)acetic acid (CAS# 19668-85-0) and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-f128e4b9a23344e1b2e31ed15a740792
Source dataset
uspto-grants-2001_03
Patent number
US06207710B1

Reaction notes

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