HRID1533654

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

结构：C[C@@H](OC(C)(C)C)[C@H](NC(=O)OC(C)(C)C)C(=O)O

HCID7015770

Boc-Thr(tBu)-OH

C13H25NO5

结构：C[C@H](NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)O

HCID53788870

未命名化合物

HCID69623029

未命名化合物

PRODUCTS

生成物

结构：CC(OC(C)(C)C)[C@H](NC(=O)[C@H](C)NC(=O)Cc1cccc([N+](=O)[O-])c1)C(=O)N1CCOCC1

HCID69622795

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

Following General Procedure C and using N-(3-nitrophenylacetyl)-L-alanine (from Example D11 above) and 4-[(S)-2-amino-3-tert-butoxybutyryl]-morpholine (prepared from N-BOC-O-tert-butyl-L-threonine (Sigma) and morpholine (Aldrich) using General Procedure M, followed by removal of the BOC-group using General Procedure P), the title compound was prepared as a solid. The reaction was monitored by tlc (Rf=0.1 in 95:5 CHCl3/MeOH) and the product was purified by silica gel chromatography using 96:4 CHCl3/MeOH as the eluent.

WORKUP

后处理

customfollowed by removal of the BOC-group
customwas prepared as a solid
customthe product was purified by silica gel chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d39bb7447824b9f8ad7581308cf35e4
来源数据集: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06207710B1
来源说明: uspto-grants-2001_03

反应 SMILES

[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C@H:14]([C:16]([OH:18])=O)[CH3:15])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH2:19][C@@H:20]([CH:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH3:30])[C:21]([N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1)=[O:22].C(N[C@H](C(O)=O)[C@@H](C)OC(C)(C)C)(OC(C)(C)C)=O.N1CCOCC1>C(Cl)(Cl)Cl.CO>[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([NH:13][C@H:14]([C:16]([NH:19][C@@H:20]([CH:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])[CH3:30])[C:21]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[O:22])=[O:18])[CH3:15])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]