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HRID1533690

反应详情

EQUATION

反应方程式

HRID 1533690 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
HCID12135350

N-[(3,5-difluorophenyl)acetyl]alanine

C11H11F2NO3

结构：COC(=O)C1CCCCN1.Cl
HCID13246231

Methyl piperidine-2-carboxylate--hydrogen chloride (1/1)

C7H14ClNO2

PRODUCTS

生成物

1
结构：COC(=O)C1CCCCN1C(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1
HCID9842199

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl pipecolinate hydrochloride (Aldrich), the title compound was prepared as a solid (mp=114-118° C.). The reaction was monitored by tlc (Rf=0.71 in 10% MeOH/DCM) and the product was purified by acid/base washes.

WORKUP

后处理

  1. customthe product was purified by acid/base washes