Benzyl 1-tert-butoxycarbonyl-2-ethoxycarbonylindole-4-carboxylate → 1-Tert-butoxycarbonyl-2-ethoxycarbonylindole-4-carboxylic acid

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Reaction Steps

To a mixture of 10% palladium on charcoal (130 mg) in 5.0% formic acid-methanol (5.0 ml) was added a solution of benzyl 1-tert-butoxycarbonyl-2-ethoxycarbonylindole-4-carboxylate (130 mg) in 5.0% formic acid-methanol (5.0 ml). The mixture was stirred under nitrogen atmosphere at ambient temperature for 30 minutes. The resulting mixture was filtered through a bed of celite and the filtrate was evaporated in vacuo to give 1-tert-butoxycarbonyl-2-ethoxycarbonylindole-4-carboxylic acid (87 mg) as a white crystal.

Provenance & Evidence