Methanol → Tetracosa-11,13-diyne

Dodec-1-yne (EGA 24,440-6) (1.2 g) was heated in the presence of copper acetate (4 g) in a mixture of pyridine (100 cm3) , methanol 300 cm3) and ether (400 cm3), for 72 h, at 30°-32° C., in the presence of a gentle stream of pure oxygen. The ether and methanol were then evaporated off under reduced pressure after the excess dissolved oxygen had been removed by the passage of argon, in the presence of 1 g of CuCl. The solution was taken up by fresh anhydrous pyridine (400 cm3) for 72 h at 47° C. (reflux). Part of the pyridine was then evaporated off under reduced pressure, after which the mixture was acidified with a 10% aqueous solution of HCl. After extraction with ether and evaporation, an oily liquid was obtained which crystallized in the cold. The oil was chromatographed in CHCl3 on SiO2 to give an oil which was transparent at room temperature (0.877 g, y=73%). The product was checked by NMR, gas chromatography (purity 97%) and mass spectroscopy (peak 330).

1. customat 30°-32° C.
2. customThe ether and methanol were then evaporated off under reduced pressure after the
3. dissolutionexcess dissolved oxygen
4. customhad been removed by the passage of argon, in the presence of 1 g of CuCl
5. waitThe solution was taken up by fresh anhydrous pyridine (400 cm3) for 72 h at 47° C.
6. temperature(reflux)
7. customPart of the pyridine was then evaporated off under reduced pressure
8. extractionAfter extraction
9. customwith ether and evaporation
10. customan oily liquid was obtained which
11. customcrystallized in the cold
12. customThe oil was chromatographed in CHCl3 on SiO2
13. customto give an oil which
14. customwas transparent at room temperature

ORD record

ord-deba32d1b1bd4c84b5b3274e9283ddc8

Source dataset

uspto-grants-1992_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05085801