Ethanol → HCID 67908627, compound

Participants

Reaction Steps

4 g of 2-bromo 5-phenyl-1,3,4-thiadiazole prepared as indicated in Tetrahedron, 1968, 24, 3214 was mixed with 6.98 g of 4-diethylamino butyn-2-yl amine prepared as indicated in Eur. J. Med. Chem. Chim. Ther., 1982, 17, 85-88. The mixture was reflux-heated in 100 ml of ethanol for 48 hours. The ethanol was concentrated in vacuo, and the residue was dissolved in a 4 N soda solution. It was extracted with ethyl acetate, then the organic phase was washed with water, dried on sodium sulphate and the residual oil was chromatographed on silica gel, using ethylacetate as the eluent.

Provenance & Evidence