反应详情

This compound was prepared by the hydrogenation of 7.7 g (0.025 mol) of N-[4-[4-(phenylmethyl)-1-piperazinyl]phenyl]acetamide in 100 mL of methanol using palladium on carbon as the catalyst. The solution was filtered and the filtrate concentrated under reduced pressure to give an oil which crystallized. The solid was dissolved in a minimum amount of a methylene chloride/10% methanol solution and passed through a 100 g Florisil column. The desired fractions were concentrated to an oil under reduced pressure which crystallized to give 3.1 g (56%) of crude product. A 0.5 g portion was recrystallized from methanol/petroleum ether to give a cream colored solid, mp 191°-193° C.

1. filtrationThe solution was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. customto give an oil which
4. customcrystallized
5. dissolutionThe solid was dissolved in a minimum amount of a methylene chloride/10% methanol solution
6. concentrationThe desired fractions were concentrated to an oil under reduced pressure which
7. customcrystallized