Potassium Iodide → 5-[2-[4-(4-Bromophenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinone

HRID 1533913Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1533913
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl[CH2:15][CH2:16][CH:17]1[O:21][C:20](=[O:22])[N:19]([CH3:23])[CH2:18]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>C(O)CCC.CC(O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:15][CH2:16][CH:17]3[O:21][C:20](=[O:22])[N:19]([CH3:23])[CH2:18]3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Komponenten

7

Edukt 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 27356291-(4-Bromophenyl)piperazineHCID 146987465-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one

Produkt 1

HCID 150300745-[2-[4-(4-Bromophenyl)-1-piperazinyl]ethyl]-3-methyl-2-oxazolidinoneAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 2631-ButanolLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

This compound was prepared according to the procedure of Example 2. A mixture of 3.6 g (0.015 mol) of 1-(4-bromophenyl)piperazine, 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 4.8 g (0.045 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol heated at reflux for 22 h gave 4.2 g (76%) of white solid, mp 125°-127° C. (2-propanol).

Aufarbeitung

  1. customThis compound was prepared
  2. temperatureheated
  3. temperatureat reflux for 22 h

Quellen und Nachweise

ORD-Eintrag
ord-94689c0621fb48f7927b7346d20edde4
Quelldatensatz
uspto-grants-1992_02
Patentnummer
US05086055

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