HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 3-Methyl-5-[2-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2-oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(4-(Trifluoromethyl)phenyl)piperazine | HCID 121718 | — |
| Reactant | 5-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one | HCID 14698746 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-Methyl-5-[2-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2-oxazolidinone | HCID 15030083 | 69% |
Reaction Steps
This compound was prepared according to the procedure of Example 2. A mixture of 3.5 g (0.015 mol) of 1-(4-trifluoromethylphenyl)piperazine (Emka-Chemie), 2.5 g (0.015 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 5.3 g (0.05 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.7 g (69%) of white solid, mp 116°-117° C. (2-propanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05086055 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-4a3828a5da614acd91fd46eecd489148 |
| Source note | uspto-grants-1992_02 |