HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 5-[2-[4-(2,6-Dimethylphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-Oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(2,6-Xylyl)piperazine | HCID 70538 | — |
| Reactant | 5-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one | HCID 14698746 | — |
| Reactant | Isopropyl alcohol isopropyl ether | HCID 21202047 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-[2-[4-(2,6-Dimethylphenyl)-1-Piperazinyl]Ethyl]-3-Methyl-2-Oxazolidinone | HCID 15030089 | 57% |
Reaction Steps
This compound was prepared according to the procedure of Example 2. A mixture of 3.8 g (0.02 mol) of 1-(2,6-dimethylphenyl)piperazine (Emka-Chemie), 3.3 g (0.02 mol) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 6.4 g (0.06 mol) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mL of 1-butanol gave 3.6 g (57%) of white solid, mp 107°-108° C. (isopropyl ether/2-propanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05086055 |
| Source dataset | uspto-grants-1992_02 |
| ORD ID | ord-b62e597d7b3744d1825b02b12c0f2459 |
| Source note | uspto-grants-1992_02 |