Bromine → HCID 15623852, compound

HRID 1534023Notes

Reaction equation

HRID 1534023 reaction equation
[C:1]([C:4]1[N:9]=[C:8]([Cl:10])[C:7]([NH2:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:12]Br>C(O)(=O)C>[C:1]([C:4]1[N:9]=[C:8]([Cl:10])[C:7]([NH2:11])=[C:6]([Br:12])[CH:5]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24408BromineHCID 15623853HCID 15623853, compound

Product 1

HCID 15623852HCID 15623852, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

15 g (88 mmol) of 6-acetyl-3-amino-2-chloropyridine are suspended in 88 ml of glacial acetic acid and 4.5 ml (88 mmol) of bromine are added dropwise. The mixture is subsequently stirred at room temperature for a further 30 minutes and then filtered off with suction and the filter cake is partitioned between NaHCO3 solution and CHCl3. The organic phase is separated off, dried with Na2SO4 and evaporated.

Workup

  1. filtrationfiltered off with suction
  2. customthe filter cake is partitioned between NaHCO3 solution and CHCl3
  3. customThe organic phase is separated off
  4. dry with materialdried with Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-7ac3cda727044f40916c8418b9d4b46a
Source dataset
uspto-grants-1992_02
Patent number
US05086181

Reaction notes

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