Dicyclohexylcarbodiimide → HCID 19882545, compound

Participants

Reaction Steps

The product from Example 17 (1.04 g), hydroxybenzotriazole hydrate (1.51 g) and thiopheneacetic acid (720mg) in dry THF (30 ml) at 0° C. was treated with dicyclohexylcarbodiimide (1.16 g). The reaction was warmed to room temperature and stirred for 18 hr. The mixture was filtered and concentrated. The residue was dissolved into EtOAc (60 ml) washed with 5% aq. HCl (15 ml), water (15 ml), 10% aq. KOH (15 ml), dried (MgSPO4) filtered and concentrated. Chromatography on SiO2 afforded 1.58 g of product as a viscous oil.

Provenance & Evidence