Triethylamine → HCID 10516251, compound

Participants

Reaction Steps

To a solution of 2.5 g of N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)thiourea produced in Example A-6 in 50 ml of THF were added 2.2 g of DCC and 0.36 g of triethylamine. The mixture was refluxed for 4 hours and evaporated in vacuo. The residue was extracted with petroleum ether. The extract was evaporated in vacuo to give N-(3,5-dichlorophenyl)-N'-(1,2,2-trimethylpropyl)carbodiimide as an oil. To a solution of this oil in 20 ml of THF were added 1.0 g of cyanamide and 1 ml of diisopropylethylamine. The mixture was refluxed for 40 hours and evaporated in vacuo. The residue was recrystallized from benzene to give 1.2 g of the title compound as colorless needles melting at 154.0°-156.0° C.

Provenance & Evidence