3-Pyrrolidinecarboxamide, 2,2,5,5-tetramethyl- → 2,2,5,5-Tetramethylpyrrolidine-3-carboxylic acid

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Reaction Steps

2,2,5,5-tetramethyl pyrroline-3-carboxylic acid was prepared by the hydrolysis of 2,2,5,5-tetramethyl pyrroline-3-carboxamide (Frinton; recrystallized from benzene) with barium hydroxide. The acid was recrystallized from water to provide an off-white solid. The measured mp was 300 (dec.) in a sealed tube; the reported mp was 300 dec. (Pauly 1902; Rozantsev 1970).

Provenance & Evidence