HCID 57423122, compound → Racemic methyl 3-{(2S)-2-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-4-morpholinyl}-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]propanoate

HRID 15342Notes

Reaction equation

HRID 15342 reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[C:12](=[CH2:17])[C:13]([O:15][CH3:16])=[O:14])=[N:9][C:8]([O:18][CH3:19])=[CH:7][CH:6]=2.CC([N:24]([CH2:28][C@@H:29]1[O:34][CH2:33][CH2:32][NH:31][CH2:30]1)[C:25](=[O:27])[O-:26])(C)C>>[CH3:2][C:11]([O:26][C:25]([NH:24][CH2:28][C@@H:29]1[O:34][CH2:33][CH2:32][N:31]([CH2:17][CH:12]([C:11]2[C:10]3[C:5](=[CH:6][CH:7]=[C:8]([O:18][CH3:19])[N:9]=3)[N:4]=[CH:3][C:2]=2[F:1])[C:13]([O:15][CH3:16])=[O:14])[CH2:30]1)=[O:27])([CH3:12])[CH3:10]

Participants

3

Reactant 2

HCID 57423122HCID 57423122, compoundHCID 57486873Methyl 2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-propenoate

Product 1

HCID 57707466Racemic methyl 3-{(2S)-2-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]-4-morpholinyl}-2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]propanoateYield 100%

Procedure

This compound was prepared from methyl 2-[3-fluoro-6-(methyloxy)-1,5-naphthyridin-4-yl]-2-propenoate and 1,1-dimethylethyl[(2R)-2-morpholinylmethyl]carbamate according to the general method of Example 2(d), in 100% yield.

Sources & evidence

ORD record
ord-936be70df389488c9e594879552cbeb3
Source dataset
uspto-grants-2010_06
Patent number
US07732461B2

Reaction notes

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